Synthesis of Some New Fluorinated Hexahydroquinoline and Acridinedione Derivatives in Trifluoroethanol

Authors

Cosmas O. Okoro, Tennessee State UniversityFollow
Mumiye A. Ogunwale, Tennessee State UniversityFollow
Tasneem Siddiquee, Tennessee State UniversityFollow

Document Type

Article

Publication Date

4-18-2012

Abstract

This article describes one-pot synthesis of new fluorinated hexahydroquinoline derivatives via unsymmetric Hantzsch reaction involving 5-trifluoromethyl-1,3-cyclohexanedione, aldehydes, acetoacetate ester, and ammonium acetate in trifluoroethanol (TFE). The reaction is simple and rapid with high yield.

Recommended Citation

Okoro, C.O.; Ogunwale, M.A.; Siddiquee, T. Synthesis of Some New Fluorinated Hexahydroquinoline and Acridinedione Derivatives in Trifluoroethanol. Appl. Sci. 2012, 2, 368-374. https://doi.org/10.3390/app2020368