Date of Award
9-1-2025
Degree Type
Thesis
Degree Name
Master of Science (M.S.)
Department
Chemistry
First Advisor
Mohammad Al-Masum
Abstract
Indole is a versatile heterocyclic scaffold renowned for its wide range of pharmacological activities and strong potential as a successful drug candidate. These attributes continue to inspire researchers to explore indole derivatives as promising leads in drug development. In this project, we report the development of a cross-coupling reaction of indoles and potassium allyltrifluoroborate to the corresponding 3-allylindoles in the presence of PdCl2(dtbpf) and PdCl2(dppf)CH2Cl2 catalyst under microwave heating, offering a rapid, regioselective, and high-yielding synthetic route. This methodology provides a valuable platform for generating structurally diverse indole-based compounds, which could serve as promising leads for further pharmacological evaluation and drug development.
Recommended Citation
Kundu, Milton Kumar, "Regioselective C-allylation of indole with potassium Allyltrifluoroborate in the presence of Pd-catalyst" (2025). Tennessee State University Alumni Theses and Dissertations. 280.
https://digitalscholarship.tnstate.edu/alumni-etd/280