Date of Award

6-2-2025

Degree Type

Thesis

Degree Name

Master of Science (M.S.)

Department

Chemistry

First Advisor

Mulugeta Wayu

Abstract

The detection and monitoring of Ascorbic Acid (AA) concentration is of crucial importance. Abnormal AA levels in bodily fluids have been reported to cause cancer, cardiovascular diseases, and Alzheimer’s and Parkinson’s diseases. Nanoparticles have played a critical role in developing affordable, sensitive, and selective sensors. This work reports on the electrochemical detection of AA using glassy carbon electrodes (GCEs) modified with microwave-assisted graphene oxide-antimony trioxide nanocomposite and chitosan films. The developed sensor displayed enhanced electron transfer and a better electrocatalytic reaction towards AA compared to other fabricated electrodes. Cyclic voltammetry and chronoamperometry were used for electrochemical measurements. CV and Fourier Transform Infrared Spectroscopy (FTIR) techniques were used for electrode surface analysis. AA oxidation peak was observed (measured on the CS/GO-Sb2O3/GCE) at 140 mV vs Ag/AgCl. Under the optimum conditions (optimum pH and temperature are 6.0 and 100 0C respectively), the sensor showed high sensitivity (95.3 A. mM-1.cm-2), lower detection limit (~10 M), wide linear responses (1 to 9 mM), and fast response (< 5s).

Download

Included in

Chemistry Commons

Share

COinS