Synthesis, characterization and antibacterial study of 4,4' and 5,5'-dicarbaldehyde-2,2'-bipyrdine and their schiff bases with sulfur and fluorine-containing amines
Design and synthesis of organic chelating agents containing nitrogen and sulfur as donor atoms and their metal complexes is an interesting field of research for their different types of activities. The bi-dentate N,N chelating agents such as 2,2-Bipyridal has been playing a vital role in synthetic and medicinal chemistry. 2,2-Bipyridine has been used to prepare many mixed-ligand complexes. Different ligand complexes prepared from 2,2-Bipyridine are used in different areas such as molecular catalysis, solar energy conversion, calorimetric analysis, herbicides, molecular recognition, self-assembly, antineoplastic agents, and nucleic acid probes. Another important properties of these type of compounds are the triplet state photosensitizing character of bipyridyl nucleus, which is shown in metal complexes. It is also found that compounds containing O,S,N atoms have received considerable attention because of their pharmacological studies like anticancer, antibacterial, and antitumor activities. Therefore, it has been decided to synthesize Schiff bases derived from 4,4' and 5,5’-dicarbaldehyde-2,2’-bipyridine compounds with O,S,N-containing amines and study their antibacterial properties. Several new Schiff bases have been synthesized and fully characterized by spectral data.
Rejaul Hoq MD.,
"Synthesis, characterization and antibacterial study of 4,4' and 5,5'-dicarbaldehyde-2,2'-bipyrdine and their schiff bases with sulfur and fluorine-containing amines"
ETD Collection for Tennessee State University.