Introducing Potassium AllylBF3K for the Synthesis of N-Allylation Products
Amine containing compounds have been important in pharmaceutical and organic chemistry due to its functional group properties. Allylated amines serve as building block for other pharmaceutical drugs. One known amination synthetic procedures is Hartwig-Buckwald amination. Hartwig-Buckwald amination, a cross-coupling reaction, is a reaction between aryl halides and amines catalyzed by catalyst with specifically designed ligands. In this project, we design a cross-coupling amination reaction and amidation reaction with potassium allyltrifluoroborate. Potassium allyltrifluoroborate (AllylBF3K) is a white crystal, robust, and more stable compared to its boronic acid form and allyl boronic ester. Due to the delocalized electrons of double bond on allyl moiety, allyl moiety is a highly reactive nucleophile. It can undergo radical reaction, polymerization or other possible unintended side reactions. Therefore, Potassium allyltrifluoroborate is a great media to transfer allyl moiety onto target compounds.
"Introducing Potassium AllylBF3K for the Synthesis of N-Allylation Products"
ETD Collection for Tennessee State University.