Establishing New Catalyst System for C-F Bond Formation by Using Organotrifluoroborates and Metal Fluoride
Fluorine containing organic compounds is getting more importance in life science industry. The most widely used modern technique in imaging is PET (Positron Emission Tomography). PET uses small isotopes such as carbon, nitrogen, fluorine and oxygen. One common application with 18F is 18F-FDG (fluoro-2-deoxy-D-dlucose). Another one is 18fluorothymidine (FLT). The half-life of 18F is 110 min. this convenient half-life makes 18F radiolabeling attractive component in image study. To find a way of making hot cell 18F chemistry, we started study cold cell fluorination chemistry. In our study, we are trying to find a new catalyst system for a mild-condition and highly regioselective fluorinated process by using organotrifluoroborates and metal fluorides under microwave irradiation. This development is presented.
Satheesh Kumar Thatiparti,
"Establishing New Catalyst System for C-F Bond Formation by Using Organotrifluoroborates and Metal Fluoride"
ETD Collection for Tennessee State University.