The Inhibition of Cellular Growth Using Dioscorea villosa on Various Cancer Cell Lines

Carey P Johnson, Tennessee State University

Abstract

In all types of cancer, some of the body’s cells begin to divide without stopping and spread into surrounding tissues. As more cases and new strains of drug-resistant cancer appear, there is a need to find an alternative and less invasive treatment to cancer. Dioscorea villosa or Wild Yam tubers have various bioactive component and several studies have reported anti-tumor, hypoglycemic, antimicrobial, and antioxidant activities of yam extracts. This study has examined the anticarcinogenic effect of crude Dioscorea villosa extract on various human lung and breast cancer cell lines (A549, BT20, BT549, and MCF7). This study seeks to compare the effectiveness of Yam extract against different cell lines. The data after experiments with multiple concentrations of Dioscorea villosa extract on various cancer cell lines, concentrations (48.4 µg/ml, 6.05 µg/ml, 3.025 µg/ml, and 0.91 µg/ml) demonstrated a dose-dependent decrease of cell growth in various cell lines. The most significant decrease is between 0.3781 and 0.7562 µg/ml of concentration 6.05 and 3.025 µg/ml and 0.1137 and 0.2275 µg/ml of concentration 0.91 µg/ml with a 54.5% difference. Concentrations 48.4, 6.05, 3.025, and 0.91 µg/ml at initial strength demonstrated very little growth versus anti-cancer agent Tamoxifen which shows an 11.2% growth. In conclusion, Dioscorea villosa extract inhibits cancer cell growth in a dose-dependent manner. Further investigations are needed to determine the cellular pathway inhibition, bioactive components, and apoptotic effects of this extract.^

Subject Area

Biology|Oncology

Recommended Citation

Carey P Johnson, "The Inhibition of Cellular Growth Using Dioscorea villosa on Various Cancer Cell Lines" (2017). ETD Collection for Tennessee State University. Paper AAI10640026.
https://digitalscholarship.tnstate.edu/dissertations/AAI10640026

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