Anti- Inflammatory Effect of Violacein on Immune Human Cells
The human immune system does important work to prevent the inflammations. Cytokines could stimulate the immunity to prohibit or enhance the inflame process. Natural killer cells, and macrophages were exposed to five concentrations (0.1 μg/ml, 0.5 μg/ml,1 μg/ml, 3 μg/ml, and 5 μg/ml) of violacein which is natural product delivered from Chromobacterium violaceum. The durations of the treatment were 24 hours and 5 days. Violacein has been indicated to play a great role as an anti-tumor, anti-bacteria, or anti-inflammation agent. In this study, the inflammatory role of violacein was demonstrated using IL-10 as an anti- inflammatory, and IL-1beta, TNF- alpha, and IFN- gamma as pro- inflammatory cytokines. The cytotoxicity of the violate pigment was also considered to see if there any effect on the immune cells. It was found that violacein presented a significant impact on the increase or decrease of the cytokines secretions. This finding can help to focus on natural products to improve drugs to defend against diseases. The interest on the inflammation procedures of violacein is to help reduce chronic inflammatory diseases.^
Kowthar Fahad Almosabbeh,
"Anti- Inflammatory Effect of Violacein on Immune Human Cells"
ETD Collection for Tennessee State University.