A new process of synthesizing anandamide derivatives from arachidonic acid in the presence of boron catalyst
Anandamide is part of the cannabinoid group and functions as a neurotransmitter. Anandamide plays a role on depression, pain, appetite, memory and fertility. Since it is well documented that anandamide analog behave as probes of the cannabinoid receptor it is of our great interest to find a new method of making new series of anandamide derivatives. Dennis Hall and his group recently reported a direct amidation process of carboxylic acid by ortho-iodo boronic acid. Applying this method, we are exploring an efficient method for amidation of arachidonic acid and carboxylic acid under microwave heating. By following our new method of using 2-ido-5-methoxyphenyl boronic acid catalyst under microwave gave the corresponding anandamide derivatives in high yield. This is a new development of using ido-boron catalyst and easily synthesizes anandamide derivatives for future study, as for example to test the biological activity of the synthesized compound.
"A new process of synthesizing anandamide derivatives from arachidonic acid in the presence of boron catalyst"
ETD Collection for Tennessee State University.