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New optical spectroscopic observations along with ultraviolet IUE observations have been obtained for the two interacting F or G III + B V binaries: HD 43246 and HD 127208. Photometric observations indicate random changes superimposed on regular ellipsoidal light variations, the latter probably the result of tidal distortion of the giant primaries. Mass transfer and loss is apparent in inverted mass ratios derived from orbital analysis, strong wind features present in the spectra, and the presence of circumsystem shells. Regular and irregular changes in the spectral features are discussed in this context.