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The blood donation process is usually very safe, and blood donors are comfortable during the blood donation procedure; however, blood donors occasionally experience various types of adverse reactions during or at the end of blood donation. Some of these reactions are very minor while blood donors sometimes experience serious reactions as well. This study aims to analyze the various types of adverse reactions experienced by the blood donors. The study conducts detailed analysis on a significant amount of real data collected through a blood organization in the southern part of the United States and provides the results regarding the frequency and types of adverse reactions based on multiple attributes such as age, gender, and donation type.