Inhibition Of PC3/MCF-7/HEL and BT20 cancer cell In Vitro By Methanol Leaf Extracts Of Cloves and Perganum

Fidaa Almuhanna, Tennessee State University


Cancer represents a category of diseases characterized by uncontrolled cell growth. Currently, there are more than 100 dissimilar cancer types. However, the type of cell that was originally affected classifies each type. As such, cancer harms the victims’ body when their affected cells start dividing irrepressibly thereby forming tumors. Consequently, these tumors may grow and affect the victims’ circulatory, nervous, digestive systems as well as produce hormones that may alter the body functioning. As a result, cancer has become one of the most dreaded diseases in the 21st century as evidenced by its percentage allocation of 25% mortality rate in the United States. However, medical practitioners are becoming more aware that they can make cancer treatment from natural compounds to fight the growing cancer risk. For example, approximately 75% of the total pharmaceuticals were discovered through the examination of plants traditionally used as medicines. Therefore, plant extracts from the leaves of cloves (Syzygium aromaticum) and Perganum (Perganum Harmala) were used in this study to determine the impact that they have on four cancer cell lines. These cancer cells included PC3, Hela, MCF7 and BT20. Subsequently, growth analysis was determined using the Alamar blue cell viability indicator or the florescent plate reader. ^ As a result, the study found that the extracts from the cloves leaf (Syzygium aromaticum) significantly inhibited the growth rate of PC3, Hela, MCF7 cell lines while the Perganum leaf extracts inhibited the growth of the BT20 tumor cell line with every additional exposure to these extracts. In the future, the study recommends that more conclusive and extensive studies be carried out to determine the real effect that the extracts have on the cancer cell lines. ^

Subject Area

Biology, Genetics|Health Sciences, Oncology

Recommended Citation

Fidaa Almuhanna, "Inhibition Of PC3/MCF-7/HEL and BT20 cancer cell In Vitro By Methanol Leaf Extracts Of Cloves and Perganum" (2014). ETD Collection for Tennessee State University. Paper AAI1585562.