Anticancer studies of curcumin, chamomile, and 1,3,4- oxadiazole derived from phenanthroline

Kholoud Alhaidari, Tennessee State University

Abstract

Curcumin and Chamomile are some of the oldest medicinal herbs used by humankind. They are versatile in their medicinal functions ranging from antioxidants to anti-inflammatory uses. Curcumin is a polyphenol found in turmeric (Curcuma longa), and Chamomile is the name given to the Asteraceae family of plants. Curcumin is commonly known for its antioxidant and anti-inflammatory abilities, and studies confirm that it is safe to use while Chamomile is associated with many benefits such as anti-histamine, anti-inflammatory, a cure for fatigue, insomnia, anxiety, and gastrointestinal disorders among many others. Users of these herbs diffuse, apply, or ingest them depending on the condition they are targeting. ^ Recent studies suggest that the two herbs are potent anti-carcinogen agents. As a result, this study aims to establish the anti-cancerous abilities of the two herbs against the synthetic anti-carcinogen agents derived from 1,3, 4-Oxadiazole, which is well-known for its pharmacological significance and its tumor weight and cell count inhibition. The experiment involves culturing cancer cell lines from the lungs, cervix, and breasts. The cells were assessed for viability and cytotoxic effects and treated with crude extracts from Curcumin and Chamomile as well as derivatives from 1,3,4-Oxadiazole. The experiments involved determining growth analysis at different concentrations, and the results were determined as mean ± standard deviation (SD). The study investigated the growth inhibiting effects of Curcumin extract on HeLa cell line from the cervix, Chamomile extract on MCF7 cell lines from the breast, Oxadiazole derivatives on A549 cell line from the lung, and BT-549 cell line from the breast. The results, as presented in graphs, showed that both the natural and synthetic agents significantly inhibited the cell line growth in all concentrations for all evaluations and that the inhibiting ability increased with an increase in concentration.^

Subject Area

Biology|Chemistry|Biochemistry

Recommended Citation

Kholoud Alhaidari, "Anticancer studies of curcumin, chamomile, and 1,3,4- oxadiazole derived from phenanthroline" (2016). ETD Collection for Tennessee State University. Paper AAI10158624.
http://digitalscholarship.tnstate.edu/dissertations/AAI10158624

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