Inhibition of Cancer Growth by O, S and N- Containing Schiff Bases Derived from 2, 2'-Bipyrdine-5,5'- dicarboxaldehyde

Zaina Alqahtani, Tennessee State University

Abstract

Cancer is an assembly of different diseases characterized by abnormal cell growth. The most common types of cancers in women include breast, cervical and ovarian. Hence, there is a need to develop or identify drugs that can effectively be used to treat cancer. In this study, we are investigating the anticancer effects of O, S and N- Containing Schiff Bases Derived from 2,2'-Bipyrdine-5,5'-dicarboxaldehyde. For simplicity, the compounds are called N1, N2 and N3. The growth analysis of the four different types of cancer cells (A549 lung cancer cells, BT549 breast cancer cells, MCF7 breast cancer cells, and PC3 prostate cancer cells) were examined using the concentrations for N1: 25, 12.5, 6.3, 3.13, 1.6, 0.78, and 0.39 μg/μl. N2: 12.5, 6.3, 3.13, 1.6, 0.78, 0.39 and 0.194 μg/μl. N3: 50, 25, 12.5, 6.3, 3.13, 1.6, and 0.78 μg/μl. Growth analysis were measured using the viability indicator Alamar Blue and fluorescent spectrophotometry. Measurements of the growth of A549 cancer cell line show a significant difference at exposures to compound N1 at 25 ug/ul and N3 at 50 ug/ul. N2 had no effect on the growth of A549. Measurements of the growth of BT549 cancer cell line show no significant difference at all concentration of N1. Measurements of the growth of MCF7 cancer cell line show a significant difference at exposures to compound N1 at 25 ug/ul and N2 at 25 ug/ul. N3 had no effect on the growth of MCF7. Measurements of the growth of PC3 cancer cell line show no significant difference at exposures to compound N1. N2 show a difference at 12.5 ug/ul and N3 at 50 and 25ug/ul. These results indicate N1, N2 and N3 may vary in the pathway that causes growth inhibition in the four cell lines. This is a positive indicator that future studies may prove to increase our understanding of growth inhibition of cancer cells.^

Subject Area

Chemistry|Biochemistry

Recommended Citation

Zaina Alqahtani, "Inhibition of Cancer Growth by O, S and N- Containing Schiff Bases Derived from 2, 2'-Bipyrdine-5,5'- dicarboxaldehyde" (2016). ETD Collection for Tennessee State University. Paper AAI10119096.
http://digitalscholarship.tnstate.edu/dissertations/AAI10119096

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