The Effect of Phytochemical Compounds on Breast, Colon, and Lung Cancer Cell Lines

Tathi Alshammari, Tennessee State University

Abstract

The National Cancer Institute asserts that about 13.7 United States citizens suffer from various cancer diseases. Besides, the cancer mortality rate in the United States stands at approximately 1600 deaths per day and 580 350 deaths annually. Globally, about 32 million people suffer from cancer while 8 million die each year due to the disease. Researchers have affirmed that traditional techniques of treating cancer are not good for human health. Therefore, researchers are left with no option but to invest in studying how herbs can be better used for cancer treatment. The main focus of this study is to examine the anticancer effects of pomegranate and capsaicin on various cancer cell lines. Besides, it will look at inhibition, and anti-inflammatory effects brought about by the two extracts. These characteristics will help in coming up with a rationale for studying the antitumor effects of the extracts.^ The extracts were obtained from various plants and put into MCF-7(breast), SW620 (colon), A549 (Lung) cell lines for 24 hours. Throughout the process, their growth analysis was examined with the aid of Alamar Blue. Both extracts exhibited some antitumor effects; however, their effectiveness varied based on which cancer cell line they were put. For instance, pomegranate seemed to be highly effective when used in SW620 (colon), A549 (Lung) Cell Lines because at high concentration of 2.4 ug/ml, its inhibition rate in was at 100%. Besides, capsaicin also seemed to be effective in both SW620 (colon), A549 (Lung) Cell Lines because when used in A549 at a high concentration of 417 mg/ml, its inhibition rate was 90%. When used in SW620, its inhibition rate was 85%. In all the experiments, there was some indication of the extracts capability to prevent cell proliferation.^ It is therefore of great importance that researchers endeavor to study pomegranate and capsaicin deeply and find out the circumstances in which they work best and their best mechanisms of action.^

Subject Area

Chemistry

Recommended Citation

Tathi Alshammari, "The Effect of Phytochemical Compounds on Breast, Colon, and Lung Cancer Cell Lines" (2016). ETD Collection for Tennessee State University. Paper AAI10119072.
http://digitalscholarship.tnstate.edu/dissertations/AAI10119072

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